Coexistence of AA and AL Cardiac Amyloidosis in a Patient with Ankylosing Spondylitis Accompanying Monoclonal Gammopathy of Undetermined Significance.
10.4078/jrd.2014.21.3.151
- Author:
Woohyeon KIM
1
;
Seon A KIM
;
Kyung Jin YUN
;
Soo Jin NA
;
Ji In HYUN
;
Jung Im JUNG
;
Seung Ki KWOK
;
Sung Hwan PARK
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. seungki73@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Cardiac amyloidosis;
Ankylosing spondylitis;
Monoclonal gammopathy of undetermined significance
- MeSH:
Amyloid;
Amyloidosis*;
Arthritis, Rheumatoid;
Humans;
Middle Aged;
Monoclonal Gammopathy of Undetermined Significance*;
Multiple Myeloma;
Spondylitis, Ankylosing*
- From:Journal of Rheumatic Diseases
2014;21(3):151-155
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Amyloidosis is a clinical disorder caused by extracellular deposition of proteinaceous insoluble fibrils in various tissues, resulting in organ compromise. Amyloid L (AL) amyloidosis is the most common type of systemic amyloidosis, which occurs in association with multiple myeloma or monoclonal gammopathy of undetermined significance (MGUS). Secondary amyloid A (AA) amyloidosis is a complication of chronic inflammatory conditions, such as rheumatoid arthritis or ankylosing spondylitis. We report a case of a 49-year-old manwith a 11-year history of ankylosing spondylitis, who was recently diagnosed with MGUS presented with cardiac amyloidosis of both the AA and AL types. We report this case along with a review of relevant literature.
