A Case of Epidermolysis Bullosa Simplex (Other Generalized Type).
- Author:
Dong Yeob KO
1
;
Seung Min HA
;
Su Young JEON
;
Dae Cheol KIM
;
Ki Hoon SONG
;
Ki Ho KIM
Author Information
1. Department of Dermatology, Dong-A University College of Medicine, Busan, Korea. khkim@dau.ac.kr
- Publication Type:Case Report
- Keywords:
Other generalized type of epidermolysis bullosa simplex
- MeSH:
Axilla;
Biopsy;
Blister;
Cell Adhesion Molecules;
Epidermolysis Bullosa;
Epidermolysis Bullosa Simplex;
Floors and Floorcoverings;
Fluorescent Antibody Technique;
Humans;
Hyperpigmentation;
Keratin-5;
Keratinocytes;
Laminin;
Light;
Methylmethacrylates;
Microscopy, Electron;
Parturition;
Pemphigoid, Bullous;
Polystyrenes;
Skin Diseases;
Thigh
- From:Korean Journal of Dermatology
2013;51(3):219-222
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The other generalized type of epidermolysis bullosa simplex (EBS) is a genetic blistering skin disease, caused by a mutation of the genes encoding keratin 5 and 14. EBS starts at birth and is characterized by generalized blisters following a minor trauma that heals with hyperpigmentation. A 19-year-old man presented with 19-year history of multiple erythematous vesicles in a herpetiform arrangement on the trunk, axilla, and thigh with post-inflammatory hyper-pigmentations. On light and electron microscopy, the biopsy specimen showed intraepidermal blisters that formed within the basal keratinocyte. The serum from a patient with bullous pemphigoid antibody and laminin 5 antibody showed the linear deposition at the floor of the blister on immunofluorescence mapping study. On the basis of our clinical, microscopic, and immunofluorescence findings, we diagnosed the patient as having a generalized type of EBS. Herein, we report on an interesting case of the other generalized type of EBS.
