A Case of Propylthiouracil induced Antineutrophil Cytoplasmic Antibody Positive Pyoderma Gangrenosum.
10.4078/jrd.2014.21.3.162
- Author:
Ji Yeon LEE
1
;
Ji Min LEE
;
Tae Han LEE
;
Hye Jin JEONG
;
Go CHOI
;
Jin Nyeong CHAE
;
Ji Min KIM
;
Sang Hyon KIM
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. mdkim9111@hanmail.net
- Publication Type:Case Report
- Keywords:
Pyoderma gangrenosum;
Propylthiouracil;
ANCA
- MeSH:
Antibodies, Antineutrophil Cytoplasmic*;
Graves Disease;
Humans;
Hyperthyroidism;
Immune System;
Isotretinoin;
Lower Extremity;
Middle Aged;
Neutrophils;
Propylthiouracil*;
Pyoderma Gangrenosum*;
Rare Diseases;
Skin Ulcer
- From:Journal of Rheumatic Diseases
2014;21(3):162-165
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pyoderma gangrenosum (PG) is a rare disease that causes chronic skin ulcers, and it has recently been known to be related to changes in the immune system such as dysfunction of neutrophils. Over 50% of patients with PG have an underlying systemic disease, and rarely are there various medicines causing the disease, including iodide, bromide, and isotretinoin. A 49-year-old man had recurrent skin ulcers in his lower extremities. He had a history of taking propylthiouracil (PTU) for 10 years as a treatment for Graves' disease. Here, we describe a case of PTU-induced ANCA positive PG in a patient with hyperthyroidism, who has been improved after the cessation of PTU.