Estimation of T2* Relaxation Time of Breast Cancer: Correlation with Clinical, Imaging and Pathological Features.
10.3348/kjr.2017.18.1.238
- Author:
Mirinae SEO
1
;
Jung Kyu RYU
;
Geon Ho JAHNG
;
Yu Mee SOHN
;
Sun Jung RHEE
;
Jang Hoon OH
;
Kyu Yeoun WON
Author Information
1. Department of Radiology, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
- Publication Type:Original Article
- Keywords:
Breast cancer;
T2*;
Relaxation time;
Susceptibility;
Breast;
Magnetic resonance imaging
- MeSH:
Breast Neoplasms*;
Breast*;
Carcinoma, Intraductal, Noninfiltrating;
Female;
Humans;
Linear Models;
Magnetic Resonance Imaging;
Multivariate Analysis;
Relaxation*
- From:Korean Journal of Radiology
2017;18(1):238-248
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The purpose of this study was to estimate the T2* relaxation time in breast cancer, and to evaluate the association between the T2* value with clinical-imaging-pathological features of breast cancer. MATERIALS AND METHODS: Between January 2011 and July 2013, 107 consecutive women with 107 breast cancers underwent multi-echo T2*-weighted imaging on a 3T clinical magnetic resonance imaging system. The Student's t test and one-way analysis of variance were used to compare the T2* values of cancer for different groups, based on the clinical-imaging-pathological features. In addition, multiple linear regression analysis was performed to find independent predictive factors associated with the T2* values. RESULTS: Of the 107 breast cancers, 92 were invasive and 15 were ductal carcinoma in situ (DCIS). The mean T2* value of invasive cancers was significantly longer than that of DCIS (p = 0.029). Signal intensity on T2-weighted imaging (T2WI) and histologic grade of invasive breast cancers showed significant correlation with T2* relaxation time in univariate and multivariate analysis. Breast cancer groups with higher signal intensity on T2WI showed longer T2* relaxation time (p = 0.005). Cancer groups with higher histologic grade showed longer T2* relaxation time (p = 0.017). CONCLUSION: The T2* value is significantly longer in invasive cancer than in DCIS. In invasive cancers, T2* relaxation time is significantly longer in higher histologic grades and high signal intensity on T2WI. Based on these preliminary data, quantitative T2* mapping has the potential to be useful in the characterization of breast cancer.
