Prediction of Neurologic Outcome of Perinatal Asphyxia by Use of CK-BB Isoenzyme Measurements.
- Author:
Hea Jin CHOEH
;
Chong Sung CHUNG
;
Kyu Chul CHOEH
- Publication Type:Original Article
- MeSH:
Asphyxia*;
Brain;
Creatine Kinase;
Humans;
Hypoxia-Ischemia, Brain;
Infant;
Infant, Newborn;
Parturition
- From:Journal of the Korean Pediatric Society
1994;37(1):19-25
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Creatine kinase (CK) isoenzyme are considered as a specific tissus injury marker. Brain type isoenzyme of CK (CK-BB) was measured in 44 healthy and 33 asphyxiated preterm and fullterm infants. Samples were drawn from periphera blood at six to ten hours after birth. There were no difference of CK-BB and CK-BB% between preterm and fullterm infants. CK-BB and CK-BB% were well correlated to the degree of hypoxic ischemic encephalopathy. Seventeen infants died in newborn period had higher CK-BB activity than 60 infants who survived at discharge. We conculuded that early CK-BB determination can be used as and indicator of neonatal brain damage and neonatal death. It is warranded to do long-term follow-up for evaluation of neurologic outcome.
