Two Cases of Pseudohypoaldosteronism Type I.
- Author:
Ji Eun LEE
;
Jung Wan SEO
;
Seung Joo LEE
- Publication Type:Case Report
- MeSH:
Acidosis;
Aldosterone;
Dehydration;
Diagnosis;
Failure to Thrive;
Humans;
Hyperkalemia;
Hyponatremia;
Infant;
Male;
Plasma;
Pseudohypoaldosteronism*;
Renin;
Sodium Chloride;
Vomiting
- From:Journal of the Korean Pediatric Society
1994;37(1):122-128
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pseudohypoaldosteronism type 1 is a genetic renal tubular disease of salt wasting, presenting in young infants. Tubular unresponsiveness to elevated endogenous and exogenous aldosterone is the suggested pathogenetic mechanism. Oral sodium chloride supplementation relieve the clinical symptoms and electrolyte distrubances. We experienced 2 cases of PHA type 1 in 38-day and 45-day old male infants who were presented with failure to thrive, vomiting and/or dehydration. Laboratory data showed hyponatremia, hyperkalemia, hypochloremia and metabolic acidosis. Renal and adrenal functions were normal. Plasma renin activity and plasma aldosterone concentration were markedly elevated. Under the diagnosis of pseudohypoaldosteronism type 1, oral supplementation of NaCl and/or kayexalate improved the clinical states of the patients.
