The Effect of Intravitreal and Subconjunctival Ciprfloxacin in the Treatment of S.Aureus Endophthalmitis.
- Author:
Hyeon Il LEE
1
;
Hyeong Jun PARK
;
Ka Young YI
Author Information
1. Department of Ophthalmology, National Medical Center, #18-79 Uljiro-6-ga, Chung-ku, Seoul, 100-196, Korea.
- Publication Type:Original Article
- Keywords:
Ciprofloxacin;
Endophthalmitis;
Staphylococcus aureus
- MeSH:
Ciprofloxacin;
Endophthalmitis*;
Intravitreal Injections;
Rabbits;
Staphylococcus aureus
- From:Journal of the Korean Ophthalmological Society
2000;41(9):1807-1814
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To investigate the therapeutic effect of ciprofloxacin for the treatment of endophthalmitis, we used 18 rabbits with Staphylococcus aureus induce dendophthalmitis. The rabbits were assigned into three groups according to the treatment regimen; those who were not given any drug into group I, those who were given 100 microgram/ml ciprofloxacin intrvitreally into group II, and those who were given 2 mg/ml ciprofloxacin subconjunctivaly for 5 days into group III. We assessed clinical score, culture result of vitreous aspirate and pathologic finding of various ocular tissue. We found clinically significant decrease in clinical score in group II, but there were no significant differences in the vitreous culture and in the histologic findings among the study groups. In conclusion, we assume that intravitreal injection of ciprofloxacin may be the better treatment modality to treat endophthalmitis by S.aureus. In addition we still think there ought to be more studies as to the determination the dosage of ciprofloxacin and the use of steroid in combination.
