A Case of Metformin-Induced Lactic Acidosis with Acute Kidney Injury Misdiagnosed as Hepatorenal Syndrome in a Cirrhosis Patient.
- Author:
Ok Ki KIM
1
;
Chan Young OAK
;
Ji Min JEONG
;
Jeong Won LEE
;
Min Ho SHIN
;
Nam Ho KIM
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. nhk@chonnam.ac.kr
- Publication Type:Case Report
- Keywords:
Metformin;
Acidosis;
Lactic;
Liver Cirrhosis;
Hepatorenal syndrome
- MeSH:
Acidosis;
Acidosis, Lactic;
Acute Kidney Injury;
Diabetes Mellitus, Type 2;
Fibrosis;
Hepatorenal Syndrome;
Humans;
Incidence;
Liver Cirrhosis;
Metformin
- From:Korean Journal of Medicine
2012;82(2):241-246
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Metformin is a well-established drug for the treatment of type 2 diabetes mellitus. The incidence of metformin-induced lactic acidosis is low, but the estimated mortality rate is approximately 50% in cases with lactic acidosis in combination with metformin therapy. Lactic acidosis occurs most often in patients with compromised cardiac, pulmonary, hepatic, and/or renal function. Acute kidney injury is a relatively frequent problem in cirrhosis patients. Hepatorenal syndrome is a diagnosis of exclusion, making its diagnosis difficult in the clinical field. We report a case of metformin-induced lactic acidosis with acute kidney injury that was misdiagnosed as hepatorenal syndrome in a cirrhosis patient.
