Synthesis and antimicrobial and antifungal activities of Base N-Mannich of 5 fluorosatin and their derivatives
- Author:
Hung Viet Tran
- Publication Type:Journal Article
- Keywords:
5-fluoroisatine
- MeSH:
Pharmaceutical Preparations;
Anti-Bacterial Agents
- From:Pharmaceutical Journal
2000;291(7):14-16
- CountryViet Nam
- Language:Vietnamese
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Abstract:
Synthesis and antibacterial and antifungal effects of some N-Mannich base of 5-fluoroisatin and their derivatives 5-fluoroisatin (I) has been prepared by the method of Sandmeyer (1919). Compound (I) underwent Mannich reaction and gave II, X with formaldehyde (36% aqueous solution) and secondary amine (morpholine and piperidine). On treatment with the appropriate arylhydrazines, compound II gave 3-arylhydrazino-5-fluoro-1-morpholinomethyl isatin (III-IX), compound X gave 3-arylhydrazino-5-fluoro-1-piperidinomethyl asatin (XI-XVI). All synthesized compounds have been characterized by IR, MS, 1H.NMR and elemental analysis. All synthesized compounds (I-XVI) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I, II, X showed an antibacterial activity against Candida albicans. Compound XIII showed an antibacterial activity on 6 strains of bacteria. Compound XIV showed an antibacterial activity on 4 strains of bacteria. Compound V showed an activity on 2 strains of bacteria and compound XV showed an antibacterial activity on 1 strain of bacteria.
