Risk factors for hospital acquired infections in patients with decompensated liver cirrhosis.
- Author:
Bong Gi CHA
1
;
Jeong Wook KIM
;
Sang Jung KIM
;
Sang Pyo HAN
;
Hyung Joon KIM
;
Jae Hyuk DO
;
Jae Gyu KIM
;
Sae Kyung CHANG
Author Information
1. Department of Internal Medicine, College of Medicine Chungang, University, Seoul, Korea. ekg001@chol.com
- Publication Type:Original Article
- Keywords:
Liver cirrhosis;
Risk factors;
Gram-negative bacterial infections;
Nosocomial infection
- MeSH:
Classification;
Cross Infection;
Gram-Negative Bacteria;
Gram-Negative Bacterial Infections;
Hemorrhage;
Humans;
Liver Cirrhosis*;
Liver Diseases;
Liver*;
Multivariate Analysis;
Risk Factors*;
Serum Albumin;
Survival Rate
- From:Korean Journal of Medicine
2005;69(1):69-75
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Infection is a frequent complication in patients with chronic liver disease, mainly during the advanced stages. This study was performed to investigate the risk factors for infections in hospitalized patients with decompensated liver cirrhosis. METHODS: We analyzed 108 decompensated hospitalized cirrhotic patients (34 cases with infection and 117 cases without infection) without clinical evidence of infection at the time of admission and during initial 72 hours after admission. RESULTS: Univariate and multivariate analysis revealed that patients who developed an infection were more likely to have a lower serum albumin levels. Gram-negative bacterial strains were detected most frequently, in 13 of the 18 strains isolated. There was no significant difference in etiology of disease, Child-Pugh classification, cirrhotic complications including upper G-I bleeding, hepatocelluar caricnoma, invasive procedure, diabetus mellitus, admission to ICU, duration of admission, survival rate and various parameters related to liver and renal function between patients with infection and without infection. CONCLUSION: The present study indicates that decompensated cirrhotic patient with low serum albumin levels have a higher risk of developing a hospital acquired infection, especially by gram negative bacteria.
