Two Cases of Advanced Bladder Carcinoma, Treated with CISCA Regimen.
- Author:
Sung Joon HONG
1
;
Chun Il KIM
;
Jin Moo LEE
Author Information
1. Department of Urology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
bladder tumor;
CISCA
- MeSH:
Carcinoma, Transitional Cell;
Cisplatin;
Cyclophosphamide;
Cystectomy;
Doxorubicin;
Drug Therapy;
Drug Therapy, Combination;
Humans;
Radiotherapy;
Urinary Bladder Neoplasms;
Urinary Bladder*
- From:Korean Journal of Urology
1986;27(1):191-194
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The CISCA regimen (Cis-platinum, Cyclophosphamide and Adriamycin combination), first reported by Sternberg et al. at 1977 is most excellent combination chemotherapy regimen for treatment of advanced bladder carcinoma other than single or combination chemotherapy regimen ever reported and its overall response rate was average 46%. We experienced two cases of advanced bladder carcinoma, treated with CISCA regimen, followed by radiotherapy and/or cystectomy. All 3 drugs (70mg/m2 Cis-platinum in five divided dose, 400mg/m2 Cyclophosphamide and 40mg/m2 Adriamycin) were given as a single dose every 1 weeks. During enforcement of each 3 and 2 cycles, the definite symptomatic relief was observed. The complications were minimal and were relatively well tolerated by patients. The chemotherapy of transitional cell carcinoma of the bladder with CISCA regimen appears to be effective.
