Quantitation of Sunburn Cell Production in Mouse Skin by Ultarviolet Irradiation.
- Author:
Gwang Yeol JOH
;
Jai Il YOUN
;
Yoo Shin LEE
- Publication Type:Original Article
- Keywords:
Sunburn cell;
Quantitative study;
Ultraviolet irradiation;
Mouse
- MeSH:
Animals;
Epidermis;
Hair;
Humans;
Male;
Mice*;
Skin*;
Sunburn*
- From:Korean Journal of Dermatology
1986;24(1):8-15
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In this study, a total of 115 ICR male albino haired mice were used and divided into two groups(A & B) for experiment. In group A(65 mice), quantiatation of sunburn cell(SBC) production and its distribution according to the time course after ultraviolet irradiation was measured. In group B(50mice), quantitation of dose-response experiments for SBC production after ultraviolet irradiation was measured. The results were as follows: ]. SBCs were recognized by 2 hours after irradiation. There was a tendency to increase from 2 hours to 24 hours and decrease from then to l week after irradiation, 2. The increase of SBCs in lower epidermis 2 hours io 8 hours after exposure and in upper epidermis 24 hours after irradiation were statistically significant (p<0. 05). SBG number in all layers declined from 36 hours to 1 week after exposure. 3. The linear relationship which observed(y=8.09+0.85x, R=0.87) suggests a dose-response relationship between UVB dose and SBC number.
