Synthesis and antibacterial and antifungal effects of 5-fluoroisatine and derivatives
- Author:
Hung Viet Tran
- Publication Type:Journal Article
- Keywords:
5-fluoroisatine
- MeSH:
Pharmaceutical Preparations;
Anti-Bacterial Agents
- From:Pharmaceutical Journal
2002;423(5):4-5
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The Sandmeyer isatin synthesis consisting of the condensation of primary arlamines with chloral and hydroxylamine to the corresponding isonitrosoacetanilides, and subsequent cyclization of the latter, was now applied with success to p-fluoroaniline, which gave 5-fluoroisatin (I). On treatment with the appropriate aryhydrazine compound I gave 3- aryhydrazine-fluoroisatin (II-VII). By the condensation of I with various p-X-C6H4NH2 compounds, 4 derivatives (VIII-XI) were formed. All synthesized compounds have been characterized by their IR and elemental analysis. 7 synthesized compounds (I-VII) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I showed an antibacterial on 8 strains of bacteria and an antifungal activity against candidia albicans. compound VI showed an antibacterial activity on 2 strains of bacteria and an antifungal activity against candidia albicans.
