A Study on the Behavioral Properties of the Rat Parkinsonian Model.
- Author:
Ha Young CHOI
1
;
Hyoung IhI KIM
;
Jae Eun KIM
;
In Seock BAHNG
;
Jung Chung LEE
Author Information
1. Department of Neurosurgery, Chonbuk National University Hospital, School of Medicine, Chonju, Korea.
- Publication Type:Original Article
- Keywords:
Parkinson's disease;
6-OHDA;
Substantia nigra;
Rotational behavior
- MeSH:
Animals;
Brain;
Dopamine;
Humans;
Oxidopamine;
Parkinson Disease;
Rats*;
Substantia Nigra;
Transplants
- From:Journal of Korean Neurosurgical Society
1989;18(2):205-213
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Recently the reports of the autologous grafting of adrenal medullary tissue into the brain of parkinsonian patient have given the wide attention to the neurosurgeons as well as other clinicians, because the current therapeutic modalities are either imperfect or palliative. Although neural grafting of adrenal medullary tissue of fetal brain which can supply the dopamine seems to be a ideal form of treatment theoretically, many problems must be overcome for this approach to be a routine procedure. Authors made the rat parkinsonian model by destroying the substantia nigra and nigrostriatal fiber selectively with 6-OHDA. And abnormal behaviors and growth patterns were observed and studied using rotometry, T-maze and metabolic cage. With the results, some parameters which would be useful in further experiments could be established.
