Reversible Leukoencephlaopathy Caused by Doxifluridine in a Patient with Gastric Cancer.
- Author:
Seong Il OH
1
;
Young Sun RYU
;
Ho Sook KIM
;
Jae Gook SHIN
;
Sang Jin KIM
Author Information
- Publication Type:Case Report
- Keywords: Doxifluridine; Reversible leukoencephalopathy; Neurotoxicity
- MeSH: Adult; Dysarthria; Female; Fluorouracil; Follow-Up Studies; Gastrectomy; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Stomach Neoplasms*
- From:Journal of the Korean Neurological Association 2016;34(1):45-48
- CountryRepublic of Korea
- Language:Korean
- Abstract: Doxifluridine neurotoxicity is more rare than 5-FU neurotoxicity. We report a case of leukoencephalopathy caused by long-term use of doxifluridine and which was resolved after discontinuation. A 37-year-old woman who had been on doxifluridine for 4 months after gastrectomy presented with dysarthria. Diffusion-weighted MRI imaging revealed multifocal hyperintense lesions in subcortical areas. Her symptoms disappeared after discontinuing doxifluridine, and lesions on follow-up MRI were resolved. These findings suggest that doxifluridine is a plausible cause of reversible leukoencephalopathy.
