Comparison of Clinicopathologic and Immunohistochemical Features between Localized and Diffuse Types of Tenosynovial Giant Cell Tumor.
- Author:
Jung Yun BAE
1
;
Kuen Tak SUH
;
Chang Hun LEE
Author Information
1. Department of Orthopaedic Surgery, Pusan National University School of Medicine, Yangsan, Korea.
- Publication Type:Original Article
- Keywords:
Tenosynovial giant cell tumor;
Immunohistochemical study;
MCSF
- MeSH:
Diagnosis, Differential;
Giant Cell Tumors*;
Giant Cells*;
Macrophage Colony-Stimulating Factor;
Recurrence;
Sensitivity and Specificity
- From:Journal of Korean Orthopaedic Research Society
2013;16(2):40-47
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Tenosynovial giant cell tumors (TSGCT) can be classified into localized and diffuse types. To identify reliable diagnostic markers for these tumors, we compared clinicopathologic and immunohistochemical features in localized and diffuse type TSGCT. MATERIALS AND METHODS: Clinicopathologic and immunohistochemical studies were perfomed. Thirty cases which had been histologically diagnosed as TSGCT after surgery, at our hospital from 2000 to 2012, were analyzed. RESULTS: There was no statistically significant difference between the groups for gender, age, site, recurrence, symptom (p>0.05). Macrophage colony-stimulating factor (MCSF), CD68, and Ki67 expression was identified in localized and diffuse type TSGCT. But there was no statistically significant difference between the groups for MCSF, CD68, and Ki67 expression (p>0.05). CONCLUSION: This study shows that although the markers MCSF, CD68, and Ki67 are expressed by localized and diffuse type TSGCT, their lack of specificity limits their use as a subsidiary immunohistochemical marker in the differential diagnosis of localized and diffuse type TSGCTs.
