Diagnostic Efficacy of FDG-PET Imaging in Solitary Pulmonary Nodule.
10.4046/trd.1996.43.6.882
- Author:
Eun Mee CHEON
1
;
Byung Tae KIM
;
O. Jung KWON
;
Hojoong KIM
;
Man Pyo CHUNG
;
Chong H. RHEE
;
Yong Chol HAN
;
Kyung Soo LEE
;
Young Mog SHIM
;
Jhingook KIM
;
Jungho HAN
Author Information
1. Division of Pulmonology, Department of Internal Medicine, Samsung Medical Center, Korea.
- Publication Type:Original Article
- Keywords:
solitary pulmonary nodule;
FDG-PET
- MeSH:
Adenocarcinoma, Bronchiolo-Alveolar;
Bronchoscopy;
Diagnosis;
Diagnosis, Differential;
Humans;
Proliferating Cell Nuclear Antigen;
Prospective Studies;
Radiography;
Sensitivity and Specificity;
Solitary Pulmonary Nodule*;
Sputum;
Thoracotomy;
Thorax
- From:Tuberculosis and Respiratory Diseases
1996;43(6):882-893
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
METHOD: 34 patients with a solitary pulmonary nodule less than 6 cm of its diameter who visited Samsung Medical Center from Semptember, 1994 to Semptember, 1995 were evaluated prospectively. Simple chest roentgenography, chest computer tomography, FDG-PET scan were performed for all patients. The results of FDG-PET were evaluated comparing with the results of final diagnosis confirmed by sputum study, PCNA, fiberoptic bronchoscopy, or thoracotomy. Results: (1) There was no significant difference in nodule size between malignant (3.1 1.5cm) and benign nodule(2.81.0cm)(P>0.05). (2) Peak SUV (standardized uptake value) of malignant nodules (6.93.7) was significantly higher than peak SUV of benign nodules(2.71.7) and time-activity curves showed continuous increase in malignant nodules. (3) Three false negative cases were found among eighteen malignant nodule by the FDG-PET imaging study and all three cases were nonmucinous bronchioloalveolar carcinoma less than 2 cm diameter. (4) FDG-PET imaging resulted in 83% sensitivity, 100% specificity, 100% positive predictive value and 84% negative predictive value. Conclusion: FDG-PET imaging is a new noninvasive diagnostic method of solitary pulmonary nodule that has a high accuracy of differential diagnosis between malignant and benign nodule. FDG-PET imaging could be used for the differential diagnosis of SPN which is not properly diagnosed with conventional methods before thoracotomy. Considering the high accuracy of FDG-PET imaging, this procedure may play an important role in making the dicision to perform thoracotomy in diffcult cases.
