A combinational effect of acetaminophen and oriental herbs on the regulation of inflammatory mediators in microglia cell line, BV2.
10.5115/acb.2015.48.4.244
- Author:
Hyemin KIM
1
;
Seyeon BAE
;
Kil Young KWON
;
Young Il HWANG
;
Jae Seung KANG
;
Wang Jae LEE
Author Information
1. Department of Anatomy, Seoul National University College of Medicine, Seoul, Korea. genius29@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Acetaminophen;
Angelica tenuissima;
Angelica dahurica;
Scutellaria baicalensis;
Microglial inflammation
- MeSH:
Acetaminophen*;
Angelica;
Cell Line*;
Cyclooxygenase 2;
Dinoprostone;
Headache;
Inflammation;
Microglia*;
Nitric Oxide;
Nitric Oxide Synthase Type II;
Scutellaria baicalensis
- From:Anatomy & Cell Biology
2015;48(4):244-250
- CountryRepublic of Korea
- Language:English
-
Abstract:
The mechanism of Western medicine that is commonly used for pain relief is well-known. However, very little is known for oriental herbs, and even less is known for mixture of the two. We investigated the combinational effect of 3 kinds of oriental herbs, usually used for the control of headache, and acetaminophen to relieve headache in microglia cell line, BV2. Lipopolysaccharide (LPS) stimulation induced to produce nitrite and increased the expression of inflammation-related factors like inducible nitric oxide synthase and cyclooxygenase-2 (COX-2) in murine microglia cell line, BV2. Oriental herbs such as Angelica tenuissima, Angelica dahurica, and Scutellaria baicalensis reduced the production of nitric oxide and the expression of COX-2. Moreover, a treatment of acetaminophen combined with oriental herbs was more decreased the COX-2 expression, and its product, prostaglandin E2 production in BV2 cells. Therefore, a combined treatment of oriental herbs such as A. tenuissima, A. dahurica, and S. baicalensis and Western medicine like acetaminophen has a synergistic effect on the decrease of LPS-induced inflammation in microglia.
