Clinical Characteristics of Developmental Regression in Autism Spectrum Disorders.
- Author:
Ji Soon KIM
1
;
Hee Jeong YOO
;
In Hee CHO
;
Tae Won PARK
;
Jung Woo SON
;
Un Sun CHUNG
;
Min Sup SHIN
;
Bung Nyun KIM
;
Jae Won KIM
;
Young Hui YANG
;
Je Wook KANG
;
Sook Hyung SONG
;
Soo Churl CHO
Author Information
1. Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea. soochurl@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Autism Spectrum Disorders;
Regression;
Autism Diagnostic Interview-Revised
- MeSH:
Adaptation, Psychological;
Appointments and Schedules;
Autistic Disorder;
Checklist;
Child;
Autism Spectrum Disorder;
Humans;
Siblings
- From:Journal of the Korean Academy of Child and Adolescent Psychiatry
2011;22(3):141-148
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: A significant proportion of children with autism spectrum disorders (ASD) have regression characterized by loss of previously acquired skills. The purpose of this study was to compare demographic, clinical characteristics and autism-related symptomatology of the children who have regression with children who don't have regression. METHODS: The subjects with ASD and their unaffected siblings (SIB) were recruited from the Korean Autism Genetic Study Consortium. Typically developing children (TC) were volunteered from community. The subjects were administered the Korean version of Autism Diagnostic Interview-Revised (K-ADI-R) and the Korean version of Autism Diagnostic Observation Schedule (K-ADOS) to diagnose or exclude ASD. Regression was defined on the basis of K-ADI-R data. The Korean version of Vineland Adaptive Behavior Scale (K-VABS), Aberrant Behavior Checklist (K-ABC) and Social Responsiveness Scale (K-SRS) were obtained from their parents. RESULTS: Regression occurred in 8.33% (n=14) of children with ASD (n=168). Any SIB (n=166) and TC (n=53) did not experience regression. Regression was associated with lower IQ and lower score of K-VABS. There was no difference in autism symptom severity and K-ABC, K-SRS scores, between children with ASD who experienced regression and who did not. CONCLUSION: Regression seems to be a distinctive feature of ASD. Regression is associated with cognitive and more general functions, rather than symptoms specific to autism.
