Role of Innate Immunity in the Pathogenesis of Type 1 and Type 2 Diabetes.
10.3346/jkms.2014.29.8.1038
- Author:
Myung Shik LEE
1
Author Information
1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. mslee0923@skku.edu
- Publication Type:Review ; Research Support, Non-U.S. Gov't
- Keywords:
Immunity, Innate;
Diabetes Mellitus;
Autoimmunity;
Lipids;
Toll-like Receptor;
Nod-like Receptor
- MeSH:
Animals;
Cytokines/*immunology;
Diabetes Mellitus, Type 1/*immunology;
Diabetes Mellitus, Type 2/*immunology;
Humans;
Immunity, Innate/*immunology;
Inflammasomes/*immunology;
*Models, Immunological;
Pancreas/immunology
- From:Journal of Korean Medical Science
2014;29(8):1038-1041
- CountryRepublic of Korea
- Language:English
-
Abstract:
The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important role in diverse pathological situations such as autoimmune diseases. Role of innate immunity in the pathogenesis of metabolic disorders such as type 2 diabetes, metabolic syndrome or atherosclerosis that has not been previously considered as inflammatory disorders, is also being appreciated. Here, the role of innate immunity in the development of type 1 diabetes, a classical organ-specific autoimmune disease, and type 2 diabetes will be discussed, focusing on the role of specific innate immune receptors involved in these disease processes.
