Acute Kidney Injury after Using Contrast during Cardiac Catheterization in Children with Heart Disease.
10.3346/jkms.2014.29.8.1102
- Author:
Young Ju HWANG
1
;
Myung Chul HYUN
;
Bong Seok CHOI
;
So Young CHUN
;
Min Hyun CHO
Author Information
1. Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea. chomh@knu.ac.kr
- Publication Type:Original Article ; Clinical Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Acute Kidney Injury;
Kidney Injury Molecule-1;
Liver-type Fatty Acid-Binding Protein;
Contrast
- MeSH:
Acute Kidney Injury/blood/*chemically induced/*urine;
Biological Markers/urine;
Cardiac Catheterization/*adverse effects;
Child;
Contrast Media/adverse effects/diagnostic use;
Fatty Acid-Binding Proteins/*urine;
Female;
Heart Defects, Congenital/complications/*radiography;
Humans;
Iohexol/adverse effects/*analogs & derivatives/diagnostic use;
Male;
Radiography, Interventional/adverse effects;
Reproducibility of Results;
Sensitivity and Specificity
- From:Journal of Korean Medical Science
2014;29(8):1102-1107
- CountryRepublic of Korea
- Language:English
-
Abstract:
Acute kidney injury (AKI) is closely associated with the mortality of hospitalized patients and long-term development of chronic kidney disease, especially in children. The purpose of our study was to assess the evidence of contrast-induced AKI after cardiac catheterization in children with heart disease and evaluate the clinical usefulness of candidate biomarkers in AKI. A total of 26 children undergoing cardiac catheterization due to various heart diseases were selected and urine and blood samples were taken at 0 hr, 6 hr, 24 hr, and 48 hr after cardiac catheterization. Until 48 hr after cardiac catheterization, there was no significant increase in serum creatinine level in all patients. Unlike urine kidney injury molecule-1, IL-18 and neutrophil gelatinase-associated lipocalin, urine liver-type fatty acid-binding protein (L-FABP) level showed biphasic pattern and the significant difference in the levels of urine L-FABP between 24 and 48 hr. We suggest that urine L-FABP can be one of the useful biomarkers to detect subclinical AKI developed by the contrast before cardiac surgery.
