Perinatal Outcome in Twin Pregnancies after in Vitro Fertilization and Embryo Transfer : Comparison between Reduced and Non-reduced Twins.
- Author:
Myung Hee KIM
;
Seok Hyun KIM
;
Byung Chul JEE
;
Chang Suk SUH
;
Young Min CHOI
;
Chang Jae SHIN
;
Jung Gu KIM
;
Shin Yong MOON
;
Jin Yong LEE
- Publication Type:In Vitro ; Original Article
- Keywords:
Assisted reproductive technology ( ART );
In vitro fertilization and embryo transfer ( IVF-ET );
Multifetal pregnancy;
Twin pregnancy;
Multifetal pregnancy reduction ( MFPR );
Perinatal outcome
- MeSH:
Birth Weight;
Embryo Transfer*;
Embryonic Structures*;
Fertilization in Vitro*;
Fetus;
Gestational Age;
Humans;
Pregnancy;
Pregnancy Complications;
Pregnancy, Triplet;
Pregnancy, Twin*
- From:Korean Journal of Obstetrics and Gynecology
1997;40(8):1586-1593
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multifetal pregnancy reduction(MFPR) has been suggested to improve pregnancy outc-ome in multifetal pregnancies with three or more fetuses after assisted reproductive techn-ology(ART) such as IVF-ET program, and now it seems to be a rather safe and effective mothod to reduce perinatal loss associated with multifetal pregnancies. To investigate the effectiveness of MFPR, the perinatal outcome of twin pregnancies in IVF-ET patients was analyzed in 3 groups : Group I-12 infertile patients who had conceived more than quadru-plet pregnancy and underwent MFPR to twin pregnancy, Group II-29 patients who had conceived triplet pregnancy and underwent MFPR to twin pregnancy, and Group III-30 pat-ients who had conceived twin pregancy initially and served as control group. Among 3 gr-oups, fetal loss rate before 24 weeks of gestation, pregnancy non-reduced, complications, gestational age at delivery, and birth weight were compared. Fetal loss rate after MFPR was significantly higher in Groups I(41.7%) and Group II(17.2%) compared with Group III(3.3%), and positively correlated with the number of fetuses before MFPR in Groups I and II. However, pregnancy complication rate was not significantly different among 3 groups(41.7%, 48.3%, and 36.7%). After exclusion of fetal loss cases before 24 weeks, mean gestational age at twin delivery and mean birth weight were not significantly different among 3 groups(36.2 weeks, 36.6 weeks, and 36.1 weeks ; 2.37 kg, 2.45 kg and 2.47kg).In conclusion, MFPR in multifetal pregnancies is an ethically justified procedure that may improve perinatal outcome in cases of multifetal pregnancies.
