Study on Effect of Conjugated Equine Estrogen and Progestogen on Serum Lipid Profiles and Bone Mineral Density in Postmenopausal Women.
- Author:
Lim CHAE
;
Han Ki YU
;
Mee Young PARK
;
Hyun Sook KIM
;
Su Kyung PARK
- Publication Type:Original Article
- MeSH:
Bone Density*;
Cholesterol;
Estrogens*;
Female;
Femur;
Hormone Replacement Therapy;
Humans;
Lipoproteins;
Medroxyprogesterone Acetate;
Metabolism;
Progesterone;
Progestins;
Spine;
Triglycerides
- From:Korean Journal of Obstetrics and Gynecology
1997;40(8):1669-1675
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hormone replacement therapy combined with progestogens induces changes in effect of estrogen on serum lipid levels and it has been known that the changes depend on a type and dosage of progestogen. It is also known that progestational agent induces positive ch-ange in bone mineral density. To study the effects of progestogen on lipoprotein and bone metabolism, we administ- ered conjugated equine estrogen 0.625 mg alone to 50 postmenopausal women, in combinat- ion with medroxy- progesterone acetate 5 mg to 40 postmenopausal women. The data demonstrated a beneficial effect in lipoprotein profiles in both groups. Total cholesterol in two groups decreased from the baseline values, LDL-cholesterol decreased significantly by 4.8 % in group I and 16.2 % in group II(p < 0.05), HDL-cholesterol increa- sed significantly by 11.3 % in group I and 14.7 % in group II(p < 0.05), triglyceride incre- ased slightly in both groups. Bone mineral density of femur was maintained and BMD of vertebrae increased by 1.1 % in group I and 2.0 % in group II, but it is not statistically significant. The differences of changes between two groups were not statistically significa- nt. Our results suggest that medroxyprogesterone acetate have no adverse effect on HDL -cholesterol and have no additive effect on bone mineral density in hormone replacement therapy.
