Association of the Tumor Necrosis Factor-alpha Gene Polymorphism with End-Stage Kidney Failure.
- Author:
Kyung Hwan JEONG
1
;
Sang Ho LEE
;
Young Jae LEE
;
Tae Won LEE
;
Chun Gyoo IHM
;
Myung Jae KIM
;
Kwan Pyo KO
;
Seung Joon OH
;
Jung Taek WOO
;
Sung Woon KIM
;
Jin Woo KIM
;
Young Seol KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Kyung-Hee University, Seoul, Korea. rulale@dreamwiz.com
- Publication Type:Original Article
- Keywords:
Cytokine polymorphism;
End-stage kidney failure;
Tumor necrosis factor-alpha;
Non insulin dependent diabetes mellitus
- MeSH:
Alleles;
Cytokines;
Diabetes Mellitus, Type 2;
Dialysis;
Gene Frequency;
Humans;
Kidney*;
Renal Insufficiency*;
Tumor Necrosis Factor-alpha*
- From:Korean Journal of Nephrology
2004;23(3):439-445
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: It is evident that cytokines play a role in the pathogenesis as well as the progression of renal diseases. The purpose of this study was to determine whether cytokine gene polymorphism is a marker of susceptibility to end-stage kidney failure (ESKF) in Korean populations. METHODS: -308 G/A polymorphism of tumor necrosis factor-alpha (TNF-alpha) gene was genotyped in 257 dialysis patients and 277 age-matched healthy controls, 86 NIDDM patients with kidney failure and 102 NIDDM controls without nephropathy. RESULTS: We found a decreased frequency of TNF-alpha allele 2 (TNF2, 2.9%) in ESKF patients compared to healthy controls (7.5%, p<0.05). We also found a decreased frequency of TNF-alpha allele 2 (TNF2, 2.3%) in NIDDM patients with kidney failure compared to NIDDM controls without nephropathy (7.6%, p<0.05). The carriage rate of TNF2 was significantly lower in NIDDM patients with kidney failure than in NIDDM controls without nephropathy (4.4% vs. 13.2%, p<0.05). In addition, allele frequency of TNF2 were remarkably different from those previously reported, indicating a significant ethnic difference. CONCLUSION: There is a significant ethnic difference in the polymorphism of TNF-alpha gene. The non-carriage TNF2 was more prevalent in the kidney failur group. But, we could not determine any association between the TNF-alpha gene polymorphism and the development of kidney failure.
