A Case of Rhabdomyolysis and Acute Renal Failure Associated with Mitochondrial Myopathy.
- Author:
Jong Hyek KIM
1
;
Young Jun ROH
;
Jee Yeon KIM
;
Sung Young MOON
;
Hyun Woo KIM
;
Jin Gun KIM
;
Joung Hun LEE
;
Jee Ho ROH
;
Byoung Cheol CHEON
;
Kwan Hang LEE
;
Shi Jung CHUNG
;
Ji Yeon RYU
Author Information
1. Department of Internal Medicine, Hanil Hospital, Seoul, Korea. manitol@medigate.net
- Publication Type:Case Report
- Keywords:
Mitochondrial myopathy;
Rhabdomyolysis;
Acute renal failure;
Ragged red fibers
- MeSH:
Acidosis;
Acute Kidney Injury*;
Azotemia;
Biopsy;
Creatinine;
Dyspnea;
Fasting;
Humans;
Hyperkalemia;
Leg;
Male;
Metabolic Networks and Pathways;
Middle Aged;
Mitochondria;
Mitochondrial Myopathies*;
Muscle Cramp;
Myoglobinuria;
Phosphotransferases;
Renal Dialysis;
Rhabdomyolysis*;
Shock
- From:Korean Journal of Nephrology
2004;23(3):509-513
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mitochondrial myopathies are diseases caused by defects in metabolic pathway of mitochondria. Mitochondrial myopathy is known as one of the causes of recurrent myoglobinuria, while clinically, rarely causes acute renal failure requiring medical treatments. We report a case of rhabdomyolysis and acute renal failure associated with mitochondrial myopathy. A 58-year-old male was presented with dyspnea and hypotensive shock. The patient had a history of recurrent dark colored urine and cramping leg pain after prolonged fasting. Laboratory findings showed hyperkalemia, azotemia, metabolic acidosis, and elevated AST, ALT, and creatinine kinase. He had no history of trauma or medication. Muscle biopsy showed "ragged red fibers" in modified Gomori staining. On electron microscope, increased number of mitochondria and abnormal mitochondria were seen. He received hemodialysis and his renal function recovered after 1 month.
