Pure Red-Cell Aplasia Due to Antibodies Against Erythropoietin.
- Author:
Jong Oh YANG
1
;
Hyo Wook GIL
;
Soon Hyo KWON
;
Young Jin CHOI
;
Eun Young LEE
;
Sae Yong HONG
Author Information
1. Department of Internal Medicine, and Clinical Research Institute, Soonchunhyang University, Chonan, Korea. eylee@sch.ac.kr
- Publication Type:Case Report
- Keywords:
Erythropoietin antibody;
Pure red- cell aplasia;
Anemia
- MeSH:
Anemia;
Antibodies*;
Bone Marrow;
Dialysis;
Erythropoietin*;
Humans;
Male;
Middle Aged;
Red-Cell Aplasia, Pure*;
Renal Dialysis
- From:Korean Journal of Nephrology
2004;23(3):528-531
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Recombinant human erythropoietin (rHuEPO) is extensively used in anemic patients on dialysis. We experienced a case of pure red-cell aplasia (PRCA) caused by anti-rHuEPO Antibody. A 48-year-old male with CRF was placed on chronic hemodialysis. He developed severe anemia (Hb 6.6 g/dL) without any apparent blood loss. A transfusion was given and the rHuEPO dose was increased to 12, 000 U/week SC. A bone marrow study was carried out. Anti-rHuEPO antibodies were positive. rHuEPO therapy was stopped. No improvement in the anemia was apparent. Although very rare, anti-rHuEPO antibodies should be evaluated in patients with severe anemia without obvious etiology.
