Effects of changes in lifestyle and biological parameters on blood lipid levels in middle aged men.
- Author:
Hoon Il KANG
1
;
Young Ho YOUN
;
Jin Yi KANG
;
Jung Jin CHO
Author Information
1. Department of Family Medicine, Seoul Hanil General Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Coronary heart disease;
Lifestyle modifications;
Diastolic blood pressure;
Uric acid;
Cholesterol;
Atherosclerogenic index
- MeSH:
Alcohol Drinking;
Blood Pressure;
Body Mass Index;
Chemistry;
Cholesterol;
Coronary Disease;
Humans;
Life Style*;
Male;
Middle Aged*;
Risk Factors;
Smoke;
Smoking;
Uric Acid;
Surveys and Questionnaires
- From:Journal of the Korean Academy of Family Medicine
2000;21(6):782-791
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Death from coronary heart disease is increasing and this study is to evaluate the effect of longitudinal changes of lifestyle and biological parameters on the blood lipid levels, as the risk factor of the coronary heart disease. METHODS: Total cholesterol and total cholesterol to HDL-cholesterol ratio (atherosclerogenic index) as an indicator for risk of coronary heart disease were examined longitudinally in a sample (n = 463) of middle-aged men by 2 years. The independent variables were body mass index, smoking, alcohol, exercise, diastolic blood pressure, uric acid. All data was drawn from questionnaire, blood chemistry, and review of chart. RESULTS: ANOVA test according to categorized variables revealed that for total cholesterol, uric acid (P<0.01) and diastolic blood pressure (P<0.01), and for atherosclerogenic index, and body mass index (P<0.001) were significant. In correlation analysis, total cholesterol was associated with uric acid (r=0.20, P<0.001), diastolic blood pressure (r=0.15, P <0.001) and body mass index (r=0.03, P<0.05), and for atherosclerogenic index so was body mass index (r=0.18, P<0.001). In regression, uric acid (beta=6.07, P <0.001), diastolic blood pressure (beta=0.36, P <0.01) for total cholesterol, and body mass index (beta=0.22, P <0.001) for atherosclerogenic index were significant. But changes in alcohol consumption, smoking, and exercise were not statistically significant. CONCLUSION: In order to reduce risks of coronary heart disease, the more aggressive medical intervention for the uric acid, DBP, and BMI, would be essential. This study was done without medical intervention. So, further study with intervention, adequate duration and intensity for parameters modification is required.
