A Histopathologic Study of the Iris in a Patient with Exfoliation Syndrome.
- Author:
Il Hoon KWAK
1
;
Sung Jun LIM
;
Myung Jin JOO
;
Jin Hyung YOO
Author Information
1. Department of Ophthalmology, College of Medicine, Inje University, Sanggye Paik Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Exfoliation syndrome;
Glycoprotein;
Basement membrane
- MeSH:
Basement Membrane;
Cataract;
Epithelium;
Exfoliation Syndrome*;
Glaucoma;
Glycoproteins;
Humans;
Iris*;
Metabolism;
Microscopy, Electron;
Microscopy, Polarization;
Tolonium Chloride
- From:Journal of the Korean Ophthalmological Society
1998;39(3):608-613
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The pathogenesis of the exfoliation syndrome is still unknown. To clarify the etiology of the exfoliation syndrome, we examined the iris taken from a patient with exfoliative glaucoma during cataract surgery using light microscope, polarization microscopy and electron microscopy. The amorphous substance around the iris pigment epithelium and stroma were stained purplish red in PAS staining and showed purplish red metachromasia in toluidine blue staining. In electromicroscopic examination, we observed that many fibrillar materials were deposited at basement membrane and partially detached basement membrane around the pigment epithelium of the iris. Therefore we concluded that the exfoliative materials in this syndrome is a sort of glycoprotein and originated from the abnormal synthesis and metabolism of the basement membrane in the eye.
