Effect of apraclonidine hydrochloride on the attack of Posner-Schlossman syndrome.
- Author:
Chul HONG
1
;
Ki Yung SONG
Author Information
- Publication Type:Original Article
- Keywords: apraclonidine; glaucomatocyclitic crisis; intraocular pressure; primaryopen-angle glaucoma
- MeSH: Adolescent; Adrenergic alpha-Agonists/*administration & dosage; Adult; Aged; Clonidine/administration & dosage/*analogs & derivatives; Female; Glaucoma, Open-Angle/drug therapy; Hemodynamics; Humans; Intraocular Pressure; Iridocyclitis/*drug therapy; Male; Middle Aged; Ocular Hypertension/*drug therapy; Ophthalmic Solutions; Syndrome
- From:Korean Journal of Ophthalmology 1993;7(1):28-33
- CountryRepublic of Korea
- Language:English
- Abstract: The intraocular pressure (IOP) of glaucomatocyclitic crisis with the attack fell 50.3%, from 37.8 +/- 8.2 mmHg to 18.8 +/- 4.8 mmHg, 4 hours after instillation of 1% apraclonidine. Glaucomatocyclitic crisis showed a more significant hypotensive response to 1% apraclonidine than primary open-angle glaucoma (24.8%, from 43. 1 +/- 8.1 mmHg to 32.4 +/- 7.5 mmHg after 4 hours). The intraocular pressure decrease percentage was similar regardless of the initial level of intraocular pressure. Clinically significant changes in mean systolic and diastolic blood pressures, were not observed, however, a mild decrease in the pulse rate was noted. And the local mydriatic effect on the pupillary diameter was significant. Apraclonidine, 1% might be newly indicated to control the IOP rise of glaucomatocyclitic crisis. Further studies on the possible mechanism of the prostaglandin mediated hypotensive effect of 1% apraclonidine are suggested.
