Estimation of Radiation Exposure of 128-Slice 4D-Perfusion CT for the Assessment of Tumor Vascularity.
10.3348/kjr.2010.11.5.547
- Author:
Dominik KETELSEN
1
;
Marius HORGER
;
Markus BUCHGEISTER
;
Michael FENCHEL
;
Christoph THOMAS
;
Nadine BOEHRINGER
;
Maximilian SCHULZE
;
Ilias TSIFLIKAS
;
Claus D CLAUSSEN
;
Martin HEUSCHMID
Author Information
1. Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany. dominik.ketelsen@med.uni-tuebingen.de
- Publication Type:Original Article
- Keywords:
Perfusion CT;
Tumor vascularity;
Radiation exposure;
Effective dose;
128-slice CT;
Alderson-Rando phantom
- MeSH:
Female;
*Four-Dimensional Computed Tomography;
Humans;
Male;
Neoplasms/*blood supply/*radiography;
Phantoms, Imaging;
*Radiation Dosage
- From:Korean Journal of Radiology
2010;11(5):547-552
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: We aimed to estimate the effective dose of 4D-Perfusion-CT protocols of the lung, liver, and pelvis for the assessment of tumor vascularity. MATERIALS AND METHODS: An Alderson-Rando phantom equipped with thermoluminescent dosimeters was used to determine the effective dose values of 4D-Perfusion-CT. Phantom measurements were performed on a 128-slice single-source scanner in adaptive 4D-spiral-mode with bidirectional table movement and a total scan range of 69 mm over a time period of nearly 120 seconds (26 scans). Perfusion measurements were simulated for the lung, liver, and pelvis under the following conditions: lung (80 kV, 60 mAs), liver (80 kV/80 mAs and 80 kV/120 mAs), pelvis (100 kV/80 mAs and 100 kV/120 mAs). RESULTS: Depending on gender, the evaluated body region and scan protocol, an effective whole-body dose between 2.9-12.2 mSv, was determined. The radiation exposure administered to gender-specific organs like the female breast tissue (lung perfusion) or to the ovaries (pelvic perfusion) led to an increase in the female specific dose by 86% and 100% in perfusion scans of the lung and the pelvis, respectively. CONCLUSION: Due to a significant radiation dose of 4D-perfusion-CT protocols, the responsible use of this new promising technique is mandatory. Gender- and organ-specific differences should be considered for indication and planning of tumor perfusion scans.
