Anaplastic Transformation of Papillary Thyroid Carcinoma in a Young Man: A Case Study with Immunohistochemical and BRAF Analysis.
- Author:
Ji Hye PARK
1
;
Hyeong Ju KWON
;
Cheong Soo PARK
;
SoonWon HONG
Author Information
1. Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Thyroid cancer, anaplastic;
Young adult;
Proto-oncogene proteins B-raf;
Immunohistochemistry
- MeSH:
Carcinoma;
Galectin 3;
Humans;
Immunohistochemistry;
Proto-Oncogene Proteins B-raf;
Recurrence;
Thyroglobulin;
Thyroid Gland;
Thyroid Neoplasms*;
Transcription Factors;
Young Adult
- From:Korean Journal of Pathology
2014;48(3):234-240
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study reports a case of anaplastic transformation from a well-differentiated thyroid carcinoma in a young patient. The first recurrent tissue contained poorly differentiated foci that revealed lower thyroglobulin, thyroid transcription factor 1 (TTF-1), and galectin-3 expression than the well-differentiated area. However there was no increased p53 or Ki-67 expression in the poorly differentiated foci, nor in the well-differentiated area. The tissue subsequently relapsed and revealed only anaplastic features, complete loss of thyroglobulin, TTF-1, and galectin-3 expression and revealed an increase in p53 and Ki-67 expression. The BRAF V600E and BRAF V600V mutation were found in the initially diagnosed papillary thyroid carcinoma and the poorly differentiated foci of the recurring papillary thyroid carcinoma; however, only the BRAF V600V mutation was found in the anaplastic carcinoma. These results suggest that overexpression of p53 and Ki-67 contributed to the anaplastic transformation. We also found that the BRAF type changed during the tumor relapse.
