Histological Changes in Ileal Reservoir Mucosa after Long-term Exposure to Urine.
- Author:
Young Jung KONG
1
;
Bong Suk SHIM
;
Young Yo PARK
Author Information
1. Department of Urology, College of Medicine, Ewha Woman University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Ileal conduit;
Intestinal mucosa;
Histological alterations
- MeSH:
Biopsy;
Colonic Pouches*;
Epithelial Cells;
Foreign-Body Reaction;
Goblet Cells;
Humans;
Intestinal Mucosa;
Metaplasia;
Microscopy, Electron;
Microvilli;
Mucous Membrane*;
Pheniramine;
Urinary Diversion
- From:Korean Journal of Urology
1994;35(9):944-948
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mucosal biopsies were obtained for histological and electron microscopical studies from 7 patients with ileal urinary conduit. Shortly after construction of the reservoir there was a reduction in villous height and an increase in crypt depth. After 2 to 3 years of observation, avillous areas were noted in the reservoir mucosa. Electron microscopy shows a loss of microvilli and a reduction of cell construction. The number of mucus-storing goblet cells increased already with in 1 month after construction. No sign of foreign body reaction, dysplasia or metaplasia was encountered. The constant exposure to urine leads to adaptive changes of the reservoir mucosa, resulting in true atropy of villi, crypts, and individual epithelial cells.
