Pharmacokinetics and dosage regimen of ceftriaxone in E. coli lipopolysaccharide induced fever in buffalo calves.
- Author:
Manmohan Singh DARDI
1
;
Suresh Kumar SHARMA
;
Anil Kumar SRIVASTAVA
Author Information
1. Department of Pharmacology and Toxicology, College of Veterinary Sciences, Punjab Agricultural University, Ludhiana-141004, India. guggujalajan@yahoo.co.in
- Publication Type:Original Article
- Keywords:
buffalo calf;
ceftriaxone;
dosage regimen;
febrile;
pharmacokinetics
- MeSH:
Animals;
Anti-Bacterial Agents/administration&dosage/*pharmacokinetics;
Area Under Curve;
Buffaloes/*metabolism;
Ceftriaxone/administration&dosage/*pharmacokinetics;
Drug Administration Schedule/veterinary;
Fever/drug therapy/*metabolism/*veterinary;
Half-Life;
Lipopolysaccharides/administration&dosage;
Male;
Metabolic Clearance Rate
- From:Journal of Veterinary Science
2005;6(2):147-150
- CountryRepublic of Korea
- Language:English
-
Abstract:
The present study was planned to investigate the pharmacokinetics of ceftriaxone in experimentally induced febrile buffalo calves (n = 5). The fever was induced by intravenous injection of E.coli lipopolysaccaride (1 microgram/kg). To study the pharmacokinetics, ceftriaxone was administered at the dose rate of 10 mg/kg body wt. in all animals. At 1 min, the peak concentration of ceftriaxone was 79.4 +/- 2.37 microgram/ml and the drug was detected up to 6 h. The elimination rate constant was 0.35 +/- 0.02 /h and elimination half-life was 2.04 +/- 0.14 h. The apparent volume of distribution (Vd(area)) and total body clearance (ClB) were 1.21 +/- 0.15 l/kg and 0.41 +/- 0.03 l/kg/h, respectively. To maintain a minimum therapeutic concentration of 1 microgram/kg, a satisfactory dosage regimen of cefriaxone in febrile buffalo calves is 19 mg/kg followed by 18 mg/kg at 8 h intervals.
