Polysaccharides isolated from Phellinus gilvus enhances dermal wound healing in streptozotocin-induced diabetic rats.
- Author:
Jae Sung BAE
;
Kwang Ho JANG
;
Hee Kyung JIN
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
diabetes;
Phellinus gilvus;
polysaccharides;
rat;
wound healing
- MeSH:
Administration, Cutaneous;
Animals;
Anti-Inflammatory Agents/pharmacology;
Basidiomycota/*metabolism;
Diabetes Mellitus, Experimental/*pathology;
Histocytochemistry;
Male;
Polysaccharides/isolation&purification/*pharmacology;
Rats;
Rats, Sprague-Dawley;
Skin/*injuries;
Streptozocin;
Wound Healing/*drug effects;
Wounds, Penetrating/*drug therapy
- From:Journal of Veterinary Science
2005;6(2):161-164
- CountryRepublic of Korea
- Language:English
-
Abstract:
Dermal wound healing is a complex process that involved inflammation leading to re-epithelialization, granulation tissue, and tissue remodeling. Previous studies from our laboratory have shown that polysaccharides isolated from fungus, Phellinus gilvus (PG) have various anti-inflammatory activities. In present study, we have assessed the effect of polysaccharides from PG on the dermal wound healing of polysaccharides from PG in streptozotocin-induced diabetic rat model. Six of 6-mm circular wounds were created with biopsy punch on the 4th day after induction of diabetes. After 24 hours, each test substance was applied to the wound twice a day for next 5 days. Circular wounds treated with PG showed significantly reduced wound contraction and complete reepithelialization, as compared to wounds of non-treated (p < 0.05). These results show that polysaccharides isolated from PG enhanced wound repair in diabetic impaired healing, and could be developed as a wound healing agent in such clinical settings.
