Brain MRI in children with delayed development: emphasis on white matter maturation.
10.3348/jkrs.1992.28.3.457
- Author:
Mi Sook SUNG
;
Ok Hwa KIM
;
Jung Lim MOON
;
Kyung Sub SHINN
;
Yong Whee BAHK
- Publication Type:Original Article
- MeSH:
Abnormalities, Multiple;
Atrophy;
Brain*;
Child*;
Corpus Callosum;
Follow-Up Studies;
Humans;
Incidence;
Infant, Newborn;
Infarction;
Leigh Disease;
Leukomalacia, Periventricular;
Lissencephaly;
Magnetic Resonance Imaging*;
Myelin Sheath;
Pathology;
Polymicrogyria;
White Matter*
- From:Journal of the Korean Radiological Society
1992;28(3):457-462
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To analyzed the progression of white matter maturation and white matter pathology, MR imaging of the brain was obtained in 38 children with delayed development. Children with developmental delay showed a high incidence of MR abnormalities(34/38, 89.5%). Delayed pattern of myelination and gray-white matter differentiation was seen in 13 patients. Twenty-two patients had white matter patholgy, including 14 with white matter hypoplasia, seven with focal small infarction, five with periventricular leukomalacia, and three with high signal intensities on T2 weighted image. Associated structural abnormalities were also evaluated. The most common lesions in decreasing frequency were cerebral atrophy and dysgenesis of the corpus callosum, pachygyria and/or polymicrogyria, porencephalic cyst and Leigh's disease. Twenty-three of 34 children had multiple abnormalities on MRI. The MRI was useful in depicting the progression of myelination and other white matter lesions, and serial follow-up MR is recommended for patients with delayed or lack of myelination and gray-white matter differentiation.
