Expression of Trans forming Growth Factor-a and Proliferating Cell Nuclear Antigen in Human Gliomas.
- Author:
Gyeong Sin LEE
;
Byung Hyun KIM
;
Bong Kwon CHUN
;
Man Ha HUH
- Publication Type:Original Article
- Keywords:
TGF-A;
PCN A;
Gliomas;
Immunohistochemistry
- MeSH:
Humans
- From:Korean Journal of Pathology
1994;28(2):149-153
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To evaluate the expression of transforming growth factor-alpha(TGF-alpha) and proliferating cell nuclear antigen(PCNA) and its relation to the differentiation of the tumors, immunohistochemical studies were performed in 49 human gliomas. Tumors were graded by a 3-grade-system; grade I=low grade glioma, grade Il=anaplastic glioma, grade III=glioblastoma multiforme. TGF-A and PCNA were predominantly expressed in malignant gliomas compared with benign gliomas. Malignant gliomas revealed 87% TGF-A reactivity, while benign gliomas revealed 26% TGF-A reactivity. The proliferation index with PCNA was 26%+/-7%(mean+/-standard deviation) in malignant gliomas and 5%?% in benign gliomas. A strong positive correlation between tumor grade and extent of TGF-A and PCNA expression was found(P<0.0001, Chi square and P<0.002, T-test). Synchronous expression of TGF-A and PCNA was observed in 16 cases(33%). The results of this study support the suggestion that the expression of TGF-A might be a useful prognostic indicator in human gliomas.