Two Cases of Simvastatin-induced Acute Myopathy.
- Author:
Seung Min KIM
1
;
Youn Min OH
;
Il Nam SUNWOO
;
Ki Jong PARK
Author Information
1. Department of Neurology, Yonsei University Medical College.
- Publication Type:Case Report
- Keywords:
Simvastatin;
Myopathy;
Cyclosporine
- MeSH:
Creatine Kinase;
Cyclosporine;
Diabetic Nephropathies;
Humans;
Kidney Transplantation;
Liver;
Muscular Diseases*;
Myalgia;
Simvastatin
- From:Journal of the Korean Neurological Association
2001;19(4):435-437
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Among the side effects of simvastatin, elevated liver enzyme or creatine kinase activity has been occasionally report-ed, but overt myopathy is rare. We report two cases of simvastatin-induced myopathy with usual dosages of simvas-tatin. Two patients presented with general myalgia, markedly elevated creatine kinase activity, and mild proximal weak-ness. One patient had been treated with concomitant use of cyclosporine and simvastatin after renal transplantation, and another patient had diabetic nephropathy. We recommend careful monitoring when myalgia appears in a patient receiv-ing simvastatin. (J Korean Neurol Assoc 19(4):435~437, 2001)
