Disseminated Mycobacterium kansasii Infection Associated with Skin Lesions: A Case Report and Comprehensive Review of the Literature.
10.3346/jkms.2010.25.2.304
- Author:
Sang Hoon HAN
1
;
Kyoung Min KIM
;
Bum Sik CHIN
;
Suk Hoon CHOI
;
Han Sung LEE
;
Myung Soo KIM
;
Su Jin JEONG
;
Hee Kyoung CHOI
;
Chang Oh KIM
;
Jun Yong CHOI
;
Young Goo SONG
;
June Myung KIM
Author Information
1. Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea. seran@yuhs.ac
- Publication Type:Case Reports ; Review
- Keywords:
Mycobacteruim kansasii;
Myelodysplastic Syndromes;
Skin;
Disseminated Infection
- MeSH:
Antitubercular Agents/therapeutic use;
Clarithromycin/therapeutic use;
Glucocorticoids/therapeutic use;
Humans;
Immunocompromised Host;
Isoniazid/therapeutic use;
Male;
Middle Aged;
Mycobacterium Infections, Nontuberculous/*diagnosis/drug therapy/immunology;
*Mycobacterium kansasii/isolation & purification;
Myelodysplastic Syndromes/drug therapy;
Rifampin/therapeutic use;
Skin Diseases, Bacterial/*diagnosis/immunology/pathology;
Sputum/microbiology;
Sweet Syndrome/diagnosis
- From:Journal of Korean Medical Science
2010;25(2):304-308
- CountryRepublic of Korea
- Language:English
-
Abstract:
Mycobacteruim kansasii occasionally causes disseminated infection with poor outcome in immunocompromised patients. We report the first case of disseminated M. kansasii infection associated with multiple skin lesions in a 48-yr-old male with myelodysplastic syndrome. The patient continuously had taken glucocorticoid during 21 months and had multiple skin lesions developed before 9 months without complete resolution until admission. Skin and mediastinoscopic paratracheal lymph node (LN) biopsies showed necrotizing granuloma with many acid-fast bacilli. M. kansasii was cultured from skin, sputum, and paratracheal LNs. The patient had been treated successfully with isoniazid, rifampin, ethmabutol, and clarithromycin, but died due to small bowel obstruction. Our case emphasizes that chronic skin lesions can lead to severe, disseminated M. kansasii infection in an immunocompromised patient. All available cases of disseminated M. kansasii infection in non HIV-infected patients reported since 1953 are comprehensively reviewed.
