Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases.
10.3346/jkms.2010.25.2.333
- Author:
Myung Ji LEE
1
;
Chul Eung KIM
Author Information
1. Department of Psychiatry, Incheon Christian Hospital, Incheon, Korea.
- Publication Type:Case Reports
- Keywords:
Clozapine;
Enuresis;
Aripiprazole;
Dopamine
- MeSH:
Adult;
Antipsychotic Agents/*adverse effects;
Clozapine/*adverse effects;
Dopamine/metabolism;
Dopamine Agonists/*therapeutic use;
Drug Therapy, Combination;
Enuresis/chemically induced/*drug therapy;
Humans;
Male;
Middle Aged;
Piperazines/*therapeutic use;
Quinolones/*therapeutic use;
Schizophrenia, Paranoid/drug therapy
- From:Journal of Korean Medical Science
2010;25(2):333-335
- CountryRepublic of Korea
- Language:English
-
Abstract:
This report describes the efficacy of combined use of aripiprazole in the treatment of a patient with clozapine induced enuresis. Aripiprazole acts as a potential dopamine partial agonist and the dopamine blockade in the basal ganglia might be one of the causes of urinary incontinence and enuresis. We speculate that aripiprazole functioned as a D2 agonist in hypodopaminergic state of basal ganglia caused by clozapine and maintained dopamine level that would improve enuresis ultimately.
