Expression of c-erbB-2 and c-met Proteins in Gastric Adenoma and Adenocarcinoma.
- Author:
Seung Woo LEE
1
;
Sang Beom KANG
;
Yon Soo KIM
;
Soon Woo NAM
;
Dong Soo LEE
;
Hye Kyung LEE
;
Sok Won HAN
Author Information
1. Departments of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. endoscope@hanmail.net
- Publication Type:Original Article ; English Abstract
- Keywords:
c-erbB-2;
c-met;
Adenoma, Gastric;
Adenocarcinoma, Gastric
- MeSH:
Adenocarcinoma/*metabolism/pathology;
Adenoma/*metabolism/pathology;
Aged;
Antibodies, Monoclonal;
Disease Progression;
Female;
Humans;
Immunohistochemistry;
Lymphatic Metastasis;
Male;
Middle Aged;
Proto-Oncogene Proteins c-met/immunology/*metabolism;
Receptor, erbB-2/immunology/*metabolism;
Stomach Neoplasms/*metabolism/pathology;
Tumor Markers, Biological
- From:The Korean Journal of Gastroenterology
2007;49(3):152-157
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The aim of this study was to investigate the immunohistochemical overexpression of c-erbB-2 and c-met proteins according to the histopathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node metastasis, and TNM stage in gastric adenoma and gastric adenocarcinoma. METHODS: Immunohistochemical staining using monoclonal c-erbB-2 and c-met antibodies was performed on paraffin embedded specimens in 43 adenomas and 44 adenocarcinomas. RESULTS: The expression rate of c-erbB-2 was higher in adenomas (91%) than adenocarcinomas (30%). The expression rate of c-met was higher in adenocarcinomas (77%) than adenomas (49%). In adenoma, the expression rate of c-met was higher in high grade dysplasia (94%) than in low grade dysplasia (22%). In adenocarcinoma, c-met expression was significantly related with lymph node metastasis. CONCLUSIONS: c-erbB-2 would be involved in the development of relatively early stage gastric carcinogenesis. c-erbB-2 is related with histologic type and c-met with lymph node metastasis in gastric carcinomas. Although meaning for the experession of these proteins in gastric carcinomas would be different, these proteins may play as important oncogenes in gastric carcinogenesis.
