Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents.
10.4062/biomolther.2015.070
- Author:
Ju Hee LEE
1
;
Ya Nan SUN
;
Young Ho KIM
;
Sang Kook LEE
;
Hyun Pyo KIM
Author Information
1. College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea. hpkim@kangwn.ac.kr
- Publication Type:Original Article
- Keywords:
Acantopanax divaricatus var. albeofructus;
Lung inflammation;
Acanthoside;
Macrophage
- MeSH:
Eleutherococcus*;
Acute Lung Injury;
Administration, Oral;
Animals;
Epithelial Cells;
Interleukin-6;
Lignans;
Lung*;
Macrophages;
Macrophages, Alveolar;
Mice;
Nitric Oxide;
Pneumonia*
- From:Biomolecules & Therapeutics
2016;24(1):67-74
- CountryRepublic of Korea
- Language:English
-
Abstract:
In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as (+)-syringaresinol (1), acanthoside B (2), salvadoraside (3) and acanthoside D (4), lariciresinol-9-O-beta-D-glucopyranoside (5) and phenylpropanoids such as 4-[(1E)-3-methoxy-1-propenyl]phenol (6), coniferin (7), and methyl caffeate (8). The extracts and several constituents such as compound 1, 6 and 8 inhibited the production of inflammatory markers, IL-6 and nitric oxide, from IL-1beta-treated lung epithelial cells and lipopolysaccharide (LPS)-treated alveolar macrophages. Furthermore, the extracts and compound 4 significantly inhibited lung inflammation in lipolysaccharide-treated acute lung injury in mice by oral administration. Thus it is suggested that A. divaricatus var. albeofructus and its several constituents may be effective against lung inflammation.
