Isolation and immunomodulatory activity of bursal peptide, a novel bursal peptide from the chicken bursa of Fabricius.
10.4142/jvs.2015.16.4.501
- Author:
Xiao Dong LIU
1
;
Yingjuan QIAN
;
Yong Sam JUNG
;
Pu Yan CHEN
Author Information
1. College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.
- Publication Type:Original Article
- Keywords:
B cell development;
bursal peptide;
immunomodulatory experiment;
immunomodulatory function
- MeSH:
Animals;
Birds;
Bursa of Fabricius*;
Cell Differentiation;
Chickens*;
Immunity, Cellular;
Influenza in Birds;
Lymphocytes;
Mice;
Stem Cells
- From:Journal of Veterinary Science
2015;16(4):501-507
- CountryRepublic of Korea
- Language:English
-
Abstract:
The bursa of Fabricius (BF), which is unique to birds, serves as the central humoral immune organ and plays a significant role in B lymphocyte differentiation. In this study, a new bursal peptide (BP-IV) was isolated from BF, which promoted colony-forming unit pre-B formation and regulated B cell differentiation. BP-IV also exerted immunomodulatory effects on antigen-specific immune responses via both humoral and cellular immunity in chicken and mice that had been immunized with inactivated avian influenza virus (AIV; H9N2 subtype), including enhancing AIV-specific antibody and cytokine production. The results of this study provided novel insights into the use of a potential candidate reagent for B cell development and future immuno-pharmacological use.
