Indocyanine Green Clearance Rate and Underlying Hepatic Inflammation and Fibrosis in Patients with Hepatocellular Carcinoma.
- Author:
Seong Jun PARK
1
;
Hyeong Gon MOON
;
Dong Chul KIM
;
Chi Young JEONG
;
Young Tae JU
;
Eun Jung JUNG
;
Young Joon LEE
;
Sang Kyung CHOI
;
Woo Song HA
;
Soon Tae PARK
;
Soon Chan HONG
Author Information
1. Department of Surgery, Postgraduate School of Medicine, Gyeongsang National University, Jinju, Korea. schong@nongae.gsnu.ac.kr
- Publication Type:Original Article
- Keywords:
Hepatocellular carcinoma;
Indocyanine green clearance;
Prognosis;
Fibrosis;
Inflammation
- MeSH:
Carcinoma, Hepatocellular;
Disease-Free Survival;
Fibrosis;
Humans;
Indocyanine Green;
Inflammation;
Liver;
Multivariate Analysis;
Prognosis;
Survival Rate
- From:Journal of the Korean Surgical Society
2008;74(4):267-273
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The indocyanine clearance rate has been identified as an independent prognostic factor in patients with hepatocellular carcinoma (HCC). However, in contrast to its well-documented value in measuring hepatic reserve function, the mechanism by which it exerts its prognostic effect is not precisely understood. METHODS: We analyzed the clinical and pathological data, including preoperative ICG-R 15 and survival, of 80 patients with resectable HCC. The correlation between ICG-R15 and the degree of inflammation and fibrosis in non-cancerous liver tissue were investigated. The prognostic significance of ICG- R15 was also investigated in 67 patients with unresectable HCC who received transarterial chemoembolization. RESULTS: In patients with resectable HCC, the low ICG group (ICG-R15<15%) showed an increased overall survival rate (P<0.001) and disease-free survival rate (P<0.01) compared to the high ICG group (ICG-R15> or =15%). ICG-R15 was also a significant prognostic factor in the multivariate analysis. ICG-R15 showed a significant correlation with the degree of necroinflammation (P<0.001) and the degree of fibrosis (P<0.001). In patients with unresectable HCC, the low ICG group (ICG-R15<30%) showed a significantly increased progression-free survival rate (P=0.037). CONCLUSION: The results of the present study demonstrate that the ICG clearance rate can predict the degree of inflammation and fibrosis of non-cancerous hepatic parenchyma, and this capacity may explain the prognostic value of the ICG clearance rate in HCC patients.
