The characteristics of extended-spectrum beta-lactamases in Korean isolates of Enterobacteriaceae.
10.3349/ymj.1998.39.6.514
- Author:
Hyunjoo PAI
1
Author Information
1. Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, Dankook University, Chonan, Korea. paihj@unitel.co.kr
- Publication Type:Original Article ; Review
- Keywords:
Extended-spectrum beta-lactamase (ESBL);
TEM-52;
SHV-12;
SHV-2a;
CMY-1;
Escherichia coli;
Klebsiella pneumoniae
- MeSH:
Drug Resistance, Microbial/physiology;
Enterobacteriaceae/isolation & purification;
Enterobacteriaceae/chemistry*;
Enterobacteriaceae Infections/microbiology;
Human;
Korea;
beta-Lactamases/analysis*
- From:Yonsei Medical Journal
1998;39(6):514-519
- CountryRepublic of Korea
- Language:English
-
Abstract:
Extended-spectrum beta-lactamases (ESBLs) in gram-negative organisms have been implicated as the enzymes responsible for resistance to oxyimino-cephalosporins. The incidence of ESBL- producers in Korean isolates of Escherichia coli and Klebsiella pneumoniae were in the range of 4.8 7.5% and 22.5 22.8%, respectively. The ESBL-producing isolates revealed variable levels of resistance to cefotaxime, ceftazidime and aztreonam. They also showed the elevated MIC values of non-beta-lactam antibiotics. SHV-12 and SHV-2a were the enzymes most frequently found in K. pneumoniae strains, but TEM-52 was the most prevalent in E. coli isolates. About 15% of ESBL-producing isolates of Enterobacteriaceae produced CMY-1 enzyme, which conferred resistance to cephamycins such as cefoxitin as well as oxyimino-cephalosporins. Thus, the most common types of ESBLs in Korea are TEM-52, SHV-12, SHV-2a, and CMY-1.
