Management of a Pregnant Patient with Graves' Disease Complicated by Propylthiouracil induced Agranulocytosis.
10.3904/kjim.2005.20.4.335
- Author:
Yoon Young CHO
1
;
Ho Sang SHON
;
Hyun Dae YOON
Author Information
1. Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. hdyoon@cu.ac.kr
- Publication Type:Case Report
- Keywords:
Agranulocytosis;
Propylthiouracil;
Pregnancy;
Graves' disease
- MeSH:
Thyroidectomy;
Recurrence;
Propylthiouracil/administration & dosage/*adverse effects;
Pregnancy Complications/*therapy;
Pregnancy;
Humans;
Graves Disease/*complications/*therapy;
Female;
Antithyroid Agents/administration & dosage/*adverse effects;
Agranulocytosis/chemically induced/*complications;
Adult
- From:The Korean Journal of Internal Medicine
2005;20(4):335-338
- CountryRepublic of Korea
- Language:English
-
Abstract:
Relapse and exacerbation of Graves' disease during pregnancy is rare, and thionamide induced agranulocytosis is an uncommon side effect. We report a case of a pregnant woman in her 24th week of gestation that experienced a relapse of Graves' disease that was complicated by propylthiouracil induced agranulocytosis. Following the discontinuation of propylthiouracil and administration of a broad-spectrum of antibiotics, agranulocytosis subsided within 10 days. A total thyroidectomy to avoid any future relapse was planned and a short course of a beta-adrenergic blocker and Lugol solution were prescribed before the operation. At the 28th week of gestation, a total thyroidectomy was performed without complications and thyroxine replacement therapy was commenced. At the 40th week of gestation, labor was induced and a 3, 370 g healthy male infant was born without clinical features of thyrotoxicosis. We report herein on the patient and the treatment options for this rare and complicated case.
