Correlation of Serum Vascular Endothelial Growth Factor and Matrix Metalloproteinase-2 in Patients Complicated with Preeclampsia and Normotensive Pregnant Women.
- Author:
Kyung Ju LEE
1
;
Min Jeong OH
;
Hai Joong KIM
;
Sun Haeng KIM
;
Jae Kwan LEE
;
Jun Young HUR
;
Ho Suk SAW
;
Yong Kyun PARK
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University, Kangnam CHA General Hospital, Korea.
- Publication Type:Original Article ; Comparative Study
- Keywords:
Vascular endothelial growth factor;
Matrix metalloproteinase-2;
Preeclampsia
- MeSH:
Female;
Humans;
Matrix Metalloproteinase 2*;
Plasma;
Pre-Eclampsia*;
Pregnant Women*;
Vascular Endothelial Growth Factor A*
- From:Korean Journal of Obstetrics and Gynecology
2005;48(1):29-35
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study is to evaluate whether serum levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) are different between normotensive pregnant women and preeclampsia patients and also to investigate the relationship of VEGF and MMP-2. METHODS: We analyzed the serum levels of VEGF and MMP-2 in patients with preeclampsia (n=20) and normotensive pregnant women (n=20). RESULTS: Of the normotensive pregnant and preeclampsia women, the serum VEGF levels are 0.28 +/- 0.14 ng/mL 2.39 +/- 0.75 ng/mL, the serum MMP-2 levels are 11.81 +/- 1.75 ng/mL, 31.99 +/- 6.5 ng/mL respectively. These serum levels are higher in preeclampsia patients than normotensive pregnant women (P<0.001) The serum VEGF levels positively relate with plasma MMP-2 levels in preeclampsia (P<0.05, r=0.78). CONCLUSION: The serum VEGF levels highly correlate with the increased MMP-2 levels in preeclampsia, which may contribute the pathophysiology of preeclampsia.
