Concentration of Non-Steroidal Anti-Inflammatory Drugs in the Pelvic Floor Muscles: An Experimental Comparative Rat Model.
10.3349/ymj.2014.55.4.1095
- Author:
Hung Yen CHIN
1
;
Eileen CHANGCHIEN
;
Mei Fung LIN
;
Chi Hsin CHIANG
;
Chin Jung WANG
Author Information
1. Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Chronic pelvic pain;
myofacial pain syndrome;
non-steroid anti-inflammation drugs;
pelvic floor muscle
- MeSH:
Animals;
Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use;
Butanones/therapeutic use;
Chronic Pain/*drug therapy;
Diclofenac/therapeutic use;
Female;
Muscles/drug effects;
Naproxen/therapeutic use;
Pelvic Floor/*pathology;
Pelvic Pain/*drug therapy;
Piroxicam/therapeutic use;
Rats;
Rats, Wistar;
Thiazines/therapeutic use;
Thiazoles/therapeutic use
- From:Yonsei Medical Journal
2014;55(4):1095-1100
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model. MATERIALS AND METHODS: We used nine NSAIDs, including nabumetone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma). RESULTS: Diclofenac potassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85+/-0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs. CONCLUSION: Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle.
