Behavioral Changes as the Earliest Clinical Manifestation of Progressive Supranuclear Palsy.

Author: Hyun Jeong HAN ¹ ; Hyeyun KIM ; Jong Ho PARK ; Hyung Woo SHIN ; Go Un KIM ; Dong Sun KIM ; Eun Ja LEE ; Hwa Eun OH ; Seung Hye PARK ; Yun Jung KIM
Author Information

1. Department of Neurology, Myongji Hospital, College of Medicine, Kwandong University, Goyang, Korea. neurohan@kd.ac.kr
Publication Type:Case Report
Keywords: frontotemporal dementia; parkinsonism; progressive supranuclear palsy
MeSH: Dihydroergotamine; Female; Frontotemporal Dementia; Gait; Humans; Middle Aged; Parkinsonian Disorders; Phenotype; Population Characteristics; Supranuclear Palsy, Progressive
From:Journal of Clinical Neurology 2010;6(3):148-151
CountryRepublic of Korea
Language:English
Abstract: BACKGROUND: The clinical and pathological heterogeneity of progressive supranuclear palsy (PSP) is well established. Even with a well-defined clinical phenotype and a thorough laboratory workup, PSP can be misdiagnosed, especially in its early stages. CASE REPORT: A 52-year-old woman, who we initially diagnosed with a behavioral variant of frontotemporal dementia developed parkinsonian features, which then progressed to gait instability and gaze abnormality. CONCLUSIONS: We report herein a pathologically confirmed case of PSP presenting with behavioral changes including agitation and irritability, which eventually led to the cardinal symptoms of progressive supranuclear palsy.