Metabolic Alterations in Parkinson's Disease after Thalamotomy, as Revealed by 1H MR Spectroscopy.
- Author:
Hyun Man BAIK
1
;
Bo Young CHOE
;
Hyoung Koo LEE
;
Tae Suk SUH
;
Byung Chul SON
;
Jae Mun LEE
Author Information
- Publication Type:Retracted Publication ; Original Article ; Duplicate Publication
- Keywords: Parkinson's disease; Thalamotomy; Metabolism; Proton magnetic resonance spectroscopy (1H MRS)
- MeSH: Adult; Aged; Aspartic Acid/*analogs & derivatives/metabolism; Brain/*metabolism/pathology; Choline/metabolism; Female; Human; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Age; Parkinson Disease/*metabolism/pathology/*surgery; Protons; Putamen/metabolism/pathology; Substantia Nigra/metabolism/pathology; Thalamus/*metabolism/pathology/*surgery
- From:Korean Journal of Radiology 2002;3(3):180-188
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To determine, using proton magnetic resonance spectroscopy (1H MRS) whether thalamotomy in patients with Parkinson's disease gives rise to significant changes in regional brain metabolism. MATERIALS AND METHODS: Fifteen patients each underwent stereotactic thalamotomy for the control of medically refractory parkinsonian tremor. Single-voxel 1H MRS was performed on a 1.5T unit using a STEAM sequence (TR/TM/TE, 2000/14/20 msec), and spectra were obtained from substantia nigra, thalamus and putamen areas, with volumes of interest of 7-8ml, before and after thalamotomy. NAA/Cho, NAA/Cr and Cho/Cr metabolite ratios were calculated from relative peak area measurements, and any changes were recorded and assessed. RESULTS: In the substantia nigra and thalamus, NAA/Cho ratios were generally low. In the substantia nigra of 80% of patients (12/15) who showed clinical improvement, decreased NAA/Cho ratios were observed in selected voxels after thalamic surgery (p < 0.05). In the thalamus of 67% of such patients (10/15), significant decreases were also noted (p < 0.05). CONCLUSION: Our results suggest that the NAA/Cho ratio may be a valuable criterion for the evaluation of Parkinson's disease patients who show clinical improvement following surgery. By highlighting variations in this ratio, 1H MRS may help lead to a better understanding of the pathophysiologic processes occurring in those with Parkinson's disease.
