Genetic predisposition of donors affects the allograft outcome in kidney transplantation: Single-nucleotide polymorphism of aquaporin-11.
10.1016/j.krcp.2015.01.002
- Author:
Ji In PARK
1
;
Seung Hee YANG
;
Jung Pyo LEE
;
Seong Ho YOO
;
Yon Su KIM
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. yonsukim@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Aquaporins;
Kidney transplantation;
Single nucleotide polymorphism
- MeSH:
Alleles;
Allografts*;
Aquaporins;
Diabetes Mellitus;
Electronic Health Records;
Gene Frequency;
Genetic Predisposition to Disease*;
Genotype;
Glycine;
Graft Survival;
Humans;
Hypertension;
Kidney Transplantation*;
Leukocytes;
Polymorphism, Single Nucleotide;
Renal Insufficiency;
Risk Factors;
Serine;
Tissue Donors*;
Transplants
- From:Kidney Research and Clinical Practice
2015;34(1):47-52
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Aquaporin-11 (AQP11) is a novel member of the aquaporin family. Disruption of the murine Aqp11 gene causes severe proximal tubular injury and renal failure. The rs2276415 (G>A) single-nucleotide polymorphism in the human AQP11 gene results in glycine to serine substitution in a functionally important domain. In this study, the role of the genetic predispositions of AQP11 rs2276415 (G>A) on renal allograft outcomes was evaluated. METHODS: A total of 198 pairs of donors and recipients were enrolled in this study. Long-term graft survival was traced and clinical parameters that could have influenced graft outcome were collected through the electronic medical record system. RESULTS: The genotype distribution and allele frequency of rs2276415 polymorphism were not different between donors and recipients. Despite similar allele frequencies between donors and recipients, the minor allele rs2276415 (GA+AA) of AQP11 from the donors, but not from the recipients, had a harmful effect on the graft survival compared with the wild-type donor (GG; P=0.029). This association was significant after adjusting for several risk factors including age, sex, human leukocyte antigen mismatch, donor type, hypertension, and diabetes mellitus (P=0.032). CONCLUSION: A donor-derived, not recipient-derived, genetic AQP11 polymorphism has different effects on graft outcome. Thus, the genetic influence from donors should be carefully considered for proper management of allografts after kidney transplantation.
